Spectroscopy can help detect metabolic alterations that occur before cognitive decline, enabling earlier intervention when treatments are most effective.
APPLICATIONS
Neurodegenerative DiseaseUse Cases
Alzheimer's Disease
MRS offers crucial insights into the underlying biochemical changes associated with Alzheimer’s Disease, such as reduced N-acetylaspartate (NAA) levels indicative of neuronal loss and increased myo-Inositol (mI) pointing to neuroinflammation. These specific metabolite markers enable healthcare professionals to monitor disease advancement and tailor interventions for Alzheimer’s patients as the condition evolves.
Magnetic Resonance Spectroscopy (MRS) aids in tracking Parkinson’s Disease progression by quantifying metabolite changes in the substantia nigra and other relevant brain regions. It can measure alterations in metabolite concentrations, such as N-acetylaspartate (NAA) and myo-Inositol (mI), offering valuable markers for measuring disease progression.
Spectroscopy provides actionable metabolic intelligence to every stakeholder.
Longevity & Concierge Medicine
MR spectroscopy provides proactive brain data to wellness-focused patients
Detect metabolic changes years before symptoms appear
Enable earlier preventative interventions
de Godoy LL, Studart-Neto A, Wylezinska-Arridge M, Tsunemi MH, Moraes NC, Yassuda MS, Coutinho AM, Buchpiguel CA, Nitrini R, Bisdas S, da Costa Leite C
The Brain Metabolic Signature in Superagers Using In Vivo 1H-MRS: A Pilot Study
BrainSpec’s automated processing frees researchers from data wrangling
Scientific Evidence
Backed by Peer-Reviewed Research
Proton magnetic resonance spectroscopy for the early diagnosis of Parkinson disease in the substantia nigra and globus pallidus: a meta-analysis with trial sequential analysis
1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults
Kara F, Joers JM, Deelchand D, Park YW, Przybelski SA, Lesnick TG, Senjem ML, Zeydan B, Knopman DS, Lowe VJ, Vemuri P, Mielke MM, Machulda MM, Jack CR Jr, Petersen RC, Öz G, Kantarci K
Higher tau is associated with lower Glu/tCr and NAA/tCr in cognitively unimpaired older adults; metabolic alterations occur before cognitive decline.
The Brain Metabolic Signature in Superagers Using In Vivo 1H-MRS: A Pilot Study
de Godoy LL, Studart-Neto A, Wylezinska-Arridge M, Tsunemi MH, Moraes NC, Yassuda MS, Coutinho AM, Buchpiguel CA, Nitrini R, Bisdas S, da Costa Leite C
Proton MR spectroscopy of mitochondrial diseases: analysis of brain metabolic abnormalities and their possible diagnostic relevance
Bianchi MC, Tosetti M, Battini R, Manca ML, Mancuso M, Cioni G, Canapicchi R, Siciliano G
Reviews the role of MR spectroscopy in diagnosing and monitoring mitochondrial diseases, highlighting characteristic metabolic patterns including elevated lactate and reduced NAA as key diagnostic indicators.
