Support neuro-oncology decision making with metabolic insight

Reveal the chemistry behind the MRI images you already acquire.

You treat IDH. MRS quantifies 2-HG.

Magnetic Resonance Spectroscopy can aid in diagnosing and monitoring brain tumors by analyzing their chemical composition, distinguishing tumor types, tracking treatment progress, and detecting potential recurrence.

APPLICATIONS

Neuro-OncologyUse Cases

From initial tumor characterization to longitudinal treatment monitoring, Magnetic Resonance Spectroscopy provides non-invasive metabolic intelligence across the full neuro-oncology care continuum.

Detection of 2-HG (IDH Mutation)

Quantify 2-hydroxyglutarate (2-HG) to non-invasively identify IDH-mutant gliomas with 95% sensitivity and 91% specificity, providing critical information about tissue composition without requiring a traditional surgical biopsy.

Suh et al., Neuro-Oncology 20(12):1573–1583, 2018
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Grading of Glial Neoplasm

Differentiate high-grade from low-grade gliomas using metabolic ratios such as Cho/NAA and Cho/Cr. Elevated choline and reduced NAA correlate with increased cellularity and neuronal loss.

Wang et al., Eur Radiol 26(8):2670–2684, 2016
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Recurrent Tumor vs. Treatment-Related Changes

Differentiate treatment-related radiation necrosis and pseudoprogression from true tumor recurrence. Both appear similar on conventional MRI, but MRS reveals distinct metabolic profiles.

El-Abtah et al., Neurooncol Adv 4(1):vdac128, 2022
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Pretreatment / Posttreatment of Neoplasm

Monitor metabolic response over time by tracking quantitative biomarkers across serial MRS scans, enabling earlier, data-driven decisions about continuing, adjusting, or changing therapy.

Shi et al., Metabolites 12(12):1219, 2022
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Wang et al., Tumour Biol 39(6), 2017
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Cystic Lesions

Characterize cystic brain lesions non-invasively by analyzing their metabolic composition. MRS can distinguish neoplastic cysts from abscesses, arachnoid cysts, and other fluid-filled lesions.

Pal et al., AJNR Am J Neuroradiol 31(2):360–366, 2010
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Who benefits

Built for theNeuro-OncologyCare Team

Spectroscopy provides actionable metabolic intelligence to every stakeholder.

Ready to Transform Your Neuro-Oncology Workflow?

Meet the BrainSpec team.