40,000+ Publications. Decades of Validation.

MR spectroscopy is one of the most extensively studied neuroimaging techniques. BrainSpec brings this vast body of evidence into clinical practice with FDA-cleared software.

Publications Library

Selected Publications

Key publications supporting the use of MRS.

Neuroimaging findings in neurofibromatosis type 1 and 2

Rodriguez D, Young Poussaint T

Neuroimaging Clinics of North America

Pediatrics
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Clinical 1H MRS in childhood neurometabolic diseases - part 2: MRS signatures

Whitehead MT, Lai LM, Blüml S

Neuroradiology

Pediatrics
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Developmental delay in children: assessment with proton MR spectroscopy

Filippi CG, Uluğ AM, Deck MD, Zimmerman RD, Heier LA

American Journal of Neuroradiology

Pediatrics
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Proton MR Spectroscopy of Pediatric Brain Disorders

Blüml S, Saunders A, Tamrazi B

Diagnostics

Pediatrics
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The use of magnetic resonance spectroscopy in the evaluation of epilepsy

Caruso PA, Johnson J, Thibert R, Rapalino O, Rincon S, Ratai EM

Neuroimaging Clinics of North America

Pediatrics
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A meta-analysis to investigate the role of magnetic resonance spectroscopy in the detection of temporal lobe epilepsy

Cui X, Zhong D, Zheng J

Advances in Clinical and Experimental Medicine

Pediatrics
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Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy following Hypothermia: A Meta-Analysis

Ouwehand S, Smidt LCA, Dudink J, Benders MJNL, de Vries LS, Groenendaal F, van der Aa NE

Neonatology

Pediatrics
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Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data

Merritt K, McGuire PK, Egerton A, 1H-MRS in Schizophrenia Investigators, Aleman A, Block W, Bloemen OJN, Borgan F, Bustillo JR, Capizzano AA, Coughlin JM, de la Fuente-Sandoval C, Demjaha A, Dempster K, Do KQ, Du F, Falkai P, Galinska-Skok B, Gallinat J, Gasparovic C, Ginestet CE, Goto N, Graff-Guerrero A, Ho BC, Howes OD, Jauhar S, Jeon P, Kato T, Kaufmann CA, Kegeles LS, Keshavan M, Kim SY, Kunugi H, Lauriello J, Liemburg EJ, McIlwain M, Modinos G, Mouchlianitis E, Nakamura J, Nenadic I, Öngür D, Ota M, Palaniyappan L, Pantelis C, Plitman E, Posporelis S, Purdon SE, Reichenbach JR, Renshaw PF, Russell BR, Sawa A, Schaefer M, Shungu DC, Smesny S, Stanley JA, Stone JM, Szulc A, Taylor R, Thakkar K, Théberge J, Tibbo PG, van Amelsvoort T, Walecki J, Williamson PC, Wood SJ, Xin L, Yamasue H

JAMA Psychiatry

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1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review

Caramanos Z, Narayanan S, Arnold DL

Brain

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MRS shows abnormalities before symptoms in familial Alzheimer disease

Godbolt AK, Waldman AD, MacManus DG, Schott JM, Frost C, Cipolotti L, Fox NC, Rossor MN

Neurology

Neurodegenerative Disease
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The Brain Metabolic Signature in Superagers Using In Vivo 1H-MRS: A Pilot Study

de Godoy LL, Studart-Neto A, Wylezinska-Arridge M, Tsunemi MH, Moraes NC, Yassuda MS, Coutinho AM, Buchpiguel CA, Nitrini R, Bisdas S, da Costa Leite C

American Journal of Neuroradiology

Neurodegenerative Disease
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Proton magnetic resonance spectroscopy for the early diagnosis of Parkinson disease in the substantia nigra and globus pallidus: a meta-analysis with trial sequential analysis

Gu W, He C, Chen J, Li J

Frontiers in Neurology

Neurodegenerative Disease
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Meta-Analysis of Neurochemical Changes Estimated via Magnetic Resonance Spectroscopy in Mild Cognitive Impairment and Alzheimer’s Disease

Liu H, Zhang D, Lin H, Zhang Q, Zheng L, Zheng Y, Yin X, Li Z, Liang S, Huang S

Frontiers in Aging Neuroscience

Neurodegenerative Disease
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Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making

Lin A, Ross BD, Harris K, Wong W

NeuroRx

Neurodegenerative Disease
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Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients

Vagnozzi R, Signoretti S, Cristofori L, Alessandrini F, Floris R, Isgrò E, Ria A, Marziali S, Marziale S, Zoccatelli G, Tavazzi B, Del Bolgia F, Sorge R, Broglio SP, McIntosh TK, Lazzarino G

Brain

Traumatic Brain Injury
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Ivosidenib and Vorasidenib Decrease Intratumoral 2-Hydroxyglutarate and Total Choline Levels in Patients with Lower-Grade Glioma: An In Vivo MR Spectroscopy Study

Simicic D, Alcicek S, Blair L, Saint-Germain M, Zöllner HJ, Ritter Z, Blakeley JO, Davies-Jenkins CW, Holdhoff M, Laterra J, Bettegowda C, Schreck KC, Lin DD, Barker PB, Kamson DO, Oeltzschner G

Clinical Cancer Research

Neuro-Oncology
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