MR spectroscopy is one of the most extensively studied neuroimaging techniques. BrainSpec brings this vast body of evidence into clinical practice with FDA-cleared software.
Publications Library
Selected Publications
Key publications supporting the use of MRS.
In vivo proton MR spectroscopy evaluation of pyogenic brain abscesses: a report of 194 cases
Pal D, Bhattacharyya A, Husain M, Prasad KN, Pandey CM, Gupta RK
N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation
Moffett JR, Arun P, Ariyannur PS, Namboodiri AM
Frontiers in Neuroenergetics
Comprehensive review of N-acetylaspartate as a neuronal health marker, documenting how NAA reductions measured by MRS serve as reliable indicators of neuronal damage across multiple brain injury types.
Metabolic Profiling with BrainSpec MRS Reveals Changes after Hematopoietic Stem Cell Transplantation in Pediatric ALD
Ratai EM, Sreepada LP, Reddigari S, Rohm L, Schunk P, Oje D, Li Y, Nagy A, Bambery M, Lin AP, Zimmerman A, Eichler F
ISMRM Abstract
Uses BrainSpec to quantify metabolic changes in pediatric adrenoleukodystrophy patients following stem cell transplant, showing measurable Cho/Cr recovery as a treatment response biomarker.
Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities
Laptook A, Garvey AA, Adams C, Grant PE, Molloy EJ, Groenendaal F, Weeke LC, Benders M, Hwang M, El-Dib M, Badawi N, Robertson NJ, Pang R, Thayyil S, Inder T, Kejlberg Andelius TC, Kyng KJ
Pediatric Research
Major consensus paper confirming MRS role as standard of care in neonatal encephalopathy assessment.
Proton MR spectroscopy of mitochondrial diseases: analysis of brain metabolic abnormalities and their possible diagnostic relevance
Bianchi MC, Tosetti M, Battini R, Manca ML, Mancuso M, Cioni G, Canapicchi R, Siciliano G
American Journal of Neuroradiology
Reviews the role of MR spectroscopy in diagnosing and monitoring mitochondrial diseases, highlighting characteristic metabolic patterns including elevated lactate and reduced NAA as key diagnostic indicators.
1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults
Kara F, Joers JM, Deelchand D, Park YW, Przybelski SA, Lesnick TG, Senjem ML, Zeydan B, Knopman DS, Lowe VJ, Vemuri P, Mielke MM, Machulda MM, Jack CR Jr, Petersen RC, Öz G, Kantarci K
Neurobiology of Aging
Higher tau is associated with lower Glu/tCr and NAA/tCr in cognitively unimpaired older adults; metabolic alterations occur before cognitive decline.
The Significance of Lactate and Lipid Peaks for Predicting Primary Neuroepithelial Tumor Grade with Proton MR Spectroscopy
Nakamura H, Doi M, Suzuki T, Yoshida Y, Hoshikawa M, Uchida M, Tanaka Y, Takagi M, Nakajima Y
Magnetic Resonance in Medical Sciences
Demonstrates that lactate and lipid peaks measured by MRS can predict neuroepithelial tumor grade non-invasively, aiding presurgical planning and treatment stratification.
Magnetic resonance spectroscopy outperforms perfusion in distinguishing between pseudoprogression and disease progression in patients with glioblastoma
El-Abtah ME, Talati P, Fu M, Chun B, Clark P, Peters A, Ranasinghe A, He J, Rapalino O, Batchelor TT, Gonzalez RG, Curry WT, Dietrich J, Gerstner ER, Ratai EM
Neuro-Oncology Advances
MRS outperforms perfusion imaging in distinguishing pseudoprogression from true tumor progression in glioblastoma patients.
2-Hydroxyglutarate MR spectroscopy for prediction of isocitrate dehydrogenase mutant glioma: a systemic review and meta-analysis using individual patient data
Suh CH, Kim HS, Jung SC, Choi CG, Kim SJ
Neuro-Oncology
Systematic review and meta-analysis establishing 2-HG MRS as a predictor of IDH mutation status — a non-invasive alternative to biopsy.
