Every year, millions of people suffer traumatic brain injuries that are invisible to standard imaging. CT scans reveal bleeding, and conventional MRI reveals structural damage, but neither can see the metabolic disruptions that underlies TBI. Spectroscopy can.
40,000+ spectroscopy publications
Reproducible metabolite outputs
Standard acquisition protocols
Daubert-tested
LANDMARK STUDY
Raji CA, Rahmani F, et al.
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BMC Neurology
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2024
Rate of Quantitative Neuroimaging Abnormalities in Chronic Traumatic Brain Injury
BrainSpec MRS identified abnormalities in 91.5% of chronic TBI cases, compared to 24.6% with visual MRI and 16.9% with DTI. Study of 65 individuals scanned median 37 months post-injury.
91.5%
Detected by BrainSpec MRS
24.6%
Detected by visual MRI
Who benefits
Built for theTBICare Team
Spectroscopy provides actionable metabolic intelligence to every stakeholder.
Clinicians
Detects subconcussive and chronic injury even when conventional imaging is normal
Enables longitudinal tracking of recovery or deterioration over time
BrainSpec Core ™ reports standardize output for straightforward interpretation
Imaging Centers
Provides an additional revenue stream from legal and insurance referrals
Differentiates your center through advanced imaging modalities
No additional hardware needed; runs on your existing MR scanner
Legal Professionals
MRS has survived Daubert in court, deemed relevant and reliable in a high-profile TBI case
BrainSpec results are simple and easily understood by a judge and jury
BrainSpec Core™ FDA clearance provides scientific credibility and reliability in court proceedings
Scientific Evidence
Backed by Peer-Reviewed Research
Rate of Quantitative Neuroimaging Abnormalities in Chronic Traumatic Brain Injury
Raji CA, Rahmani F, et al.
BrainSpec MRS identified abnormalities in 91.5% of chronic TBI cases, compared to 24.6% with visual MRI and 16.9% with DTI. Study of 65 individuals scanned median 37 months post-injury.
Associations Between Neurochemistry and Gait Performance Following Concussion in Collegiate Athletes
Charney MF, Howell DR, Lanois C, Starr TC, Liao H, Coello E, Breedlove KM, Meehan WP 3rd, Koerte IK, Lin AP
Links MRS-identified neurochemical changes in the brain to measurable gait abnormalities following concussion, providing objective evidence of functional impairment correlated with metabolic injury.
Altered Neurochemistry in Former Professional Soccer Players without a History of Concussion
Koerte IK, Lin AP, Muehlmann M, Merugumala S, Liao H, Starr T, Kaufmann D, Mayinger M, Steffinger D, Fisch B, Karch S, Heinen F, Ertl-Wagner B, Reiser M, Stern RA, Zafonte R, Shenton ME
Former professional soccer players with no diagnosed concussions showed elevated choline and myo-inositol, correlating with cumulative head impact exposure.
Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients
Vagnozzi R, Signoretti S, Cristofori L, Alessandrini F, Floris R, Isgrò E, Ria A, Marziali S, Marziale S, Zoccatelli G, Tavazzi B, Del Bolgia F, Sorge R, Broglio SP, McIntosh TK, Lazzarino G
Proton MR spectroscopy and MRI-volumetry in mild traumatic brain injury
Cohen BA, Inglese M, Rusinek H, Babb JS, Grossman RI, Gonen O
Combines volumetric MRI with MR spectroscopy to identify neurochemical changes in mild TBI patients, demonstrating that metabolic alterations are detectable even when structural imaging appears normal.
