Standardized MRS Biomarker Endpoints for Your Research

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The Platform

BrainSpec is built for your research needs

Multi-Site Research

BrainSpec reduces the vendor-specific variability that has historically limited MR spectroscopy adoption in clinical trials.

Standardized Analysis

Reproducible, quantitative MRS analysis across sites using harmonized processing pipelines reduces inter-operator variability.

Scanner-Agnostic Processing

Multi-vendor support for GE, Siemens, and Philips scanners ensures consistent data.

Automated Quality Control

Built-in QC checks flag substandard acquisitions or poor quality, ensuring data integrity.

Cloud-Based Platform

Access from anywhere with centralized data management. No local software installations required across research sites.

Reference Database

Compare patient data against reference intervals for objective, quantitative assessment of metabolite levels.

MULTI-SITE TRIALS

Eliminating Variability Across Sites

The biggest challenge in multi-site MR spectroscopy research is consistency. BrainSpec was built to solve this.

Traditional Multi-Site MR Spectroscopy

  • Variable processing across sites
  • Scanner-specific artifacts
  • Manual quality assessment
  • No reference data

With BrainSpec

  • Centralized, harmonized processing pipeline
  • GE, Siemens, Philips compatibility
  • Automated quality control flags
  • Built-in reference database
APPLICATIONS

Benefits

MR spectroscopy biomarkers unlock a wide range of research applications, from established indications to novel discovery.

FDA-Cleared Conditions

Utilize BrainSpec Core™ existing FDA-clearance across a broad range of neurological conditions, applied in the clinical trial world.

Professional Services

Leverage the BrainSpec team’s 30+ years of spectroscopy expertise for study protocol design and research support into novel chemical signatures.

Longitudinal Tracking

Track metabolite concentrations over time to objectively measure the neurochemical changes in the brain.

Treatment Response Biomarkers

Support treatment response monitoring of chemical changes in advance of anatomical changes. [1]

[1]

Simicic et al., Clin Cancer Res 32(15):3258–3268, 2026

Scientific Evidence

Backed by Peer-Reviewed Research

Ivosidenib and Vorasidenib Decrease Intratumoral 2-Hydroxyglutarate and Total Choline Levels in Patients with Lower-Grade Glioma: An In Vivo MR Spectroscopy Study

Simicic D, Alcicek S, Blair L, Saint-Germain M, Zöllner HJ, Ritter Z, Blakeley JO, Davies-Jenkins CW, Holdhoff M, Laterra J, Bettegowda C, Schreck KC, Lin DD, Barker PB, Kamson DO, Oeltzschner G

Clinical Cancer Research

View publication

Clinical Trials Utilizing MRS as a Biomarker

Lin AP, Rowland B, Griffiths, JR

eMagRes

488 clinical trials found using MRS as a biomarker endpoint.

View publication

Want BrainSpec in Your Clinical Trial?

Get in touch with our team to discuss the right BrainSpec platform for your application.