MR spectroscopy is one of the most extensively studied neuroimaging techniques. BrainSpec brings this vast body of evidence into clinical practice with FDA-cleared software.
Publications Library
Selected Publications
Key publications supporting the use of MRS.
Associations Between Neurochemistry and Gait Performance Following Concussion in Collegiate Athletes
Charney MF, Howell DR, Lanois C, Starr TC, Liao H, Coello E, Breedlove KM, Meehan WP 3rd, Koerte IK, Lin AP
Journal of Head Trauma Rehabilitation
Links MRS-identified neurochemical changes in the brain to measurable gait abnormalities following concussion, providing objective evidence of functional impairment correlated with metabolic injury.
Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury
Friedman SD, Brooks WM, Jung RE, Hart BL, Yeo RA
American Journal of Neuroradiology
Establishes a direct correlation between MRS-measured metabolite levels and neuropsychological test performance in TBI patients, supporting MRS as an objective biomarker of cognitive function.
Proton MR spectroscopy and MRI-volumetry in mild traumatic brain injury
Cohen BA, Inglese M, Rusinek H, Babb JS, Grossman RI, Gonen O
American Journal of Neuroradiology
Combines volumetric MRI with MR spectroscopy to identify neurochemical changes in mild TBI patients, demonstrating that metabolic alterations are detectable even when structural imaging appears normal.
Proton MRS in acute traumatic brain injury: role for glutamate/glutamine and choline for outcome prediction
Shutter L, Tong KA, Holshouser BA
Journal of Neurotrauma
Demonstrates the utility of proton MRS for detecting metabolic disruption in the acute phase of TBI, showing NAA reduction and choline elevation as early biomarkers of injury severity.
Altered Neurochemistry in Former Professional Soccer Players without a History of Concussion
Koerte IK, Lin AP, Muehlmann M, Merugumala S, Liao H, Starr T, Kaufmann D, Mayinger M, Steffinger D, Fisch B, Karch S, Heinen F, Ertl-Wagner B, Reiser M, Stern RA, Zafonte R, Shenton ME
Journal of Neurotrauma
Former professional soccer players with no diagnosed concussions showed elevated choline and myo-inositol, correlating with cumulative head impact exposure.
Rate of Quantitative Neuroimaging Abnormalities in Chronic Traumatic Brain Injury
Raji CA, Rahmani F, et al.
BMC Neurology
BrainSpec MRS identified abnormalities in 91.5% of chronic TBI cases, compared to 24.6% with visual MRI and 16.9% with DTI. Study of 65 individuals scanned median 37 months post-injury.
